Trifluoroacetic acid → HCID 12096118, compound

HRID 347731Notes

Reaction equation

HRID 347731 reaction equation
C[O:2][C:3](=[O:35])[C@@H:4]([NH:28][C:29]([O:31][CH:32]([CH3:34])[CH3:33])=[O:30])[CH2:5][NH:6][C:7]([CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]3[NH:23][CH2:24][CH2:25][CH2:26][N:27]=3)[CH:16]=2)[CH2:11][CH2:10]1)=[O:8].[OH-].[Na+].FC(F)(F)C(O)=O>CO>[CH:32]([O:31][C:29]([NH:28][C@@H:4]([CH2:5][NH:6][C:7]([CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]3[NH:23][CH2:24][CH2:25][CH2:26][N:27]=3)[CH:16]=2)[CH2:11][CH2:10]1)=[O:8])[C:3]([OH:35])=[O:2])=[O:30])([CH3:34])[CH3:33]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 12096117HCID 12096117, compound

Product 1

HCID 12096118HCID 12096118, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of the compound of Example 43 in methanol (5 ml) is added 2M aqueous sodium hydroxide solution (5 ml), and the mixture is stirred at 25° C. overnight. The reaction solution is neutralized with trifluoroacetic acid, and purified by CHP-20 (eluent: gradient, 35% to 100% methanol/0.05% aqueous trifluoroacetic acid solution) to give the title compound (40 mg).

Workup

  1. custompurified by CHP-20 (eluent: gradient, 35% to 100% methanol/0.05% aqueous trifluoroacetic acid solution)

Sources & evidence

ORD record
ord-a8d953b1b7f7498bbd235d9bc2769c7c
Source dataset
uspto-grants-2007_02
Patent number
US07176199B2

Reaction notes

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