Trifluoroacetic acid → HCID 12096123, compound

HRID 347733Notes

Reaction equation

HRID 347733 reaction equation
C([O:5][C:6](=[O:42])[C@@H:7]([NH:31][C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33])[CH2:8][CH2:9][C:10]([N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([NH:24][C:25]3[NH:26][CH2:27][CH2:28][CH2:29][N:30]=3)[CH:19]=2)[CH2:14][CH2:13]1)=[O:11])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:35]([O:34][C:32]([NH:31][C@@H:7]([CH2:8][CH2:9][C:10]([N:12]1[CH2:13][CH2:14][CH:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([NH:24][C:25]3[NH:26][CH2:27][CH2:28][CH2:29][N:30]=3)[CH:19]=2)[CH2:16][CH2:17]1)=[O:11])[C:6]([OH:42])=[O:5])=[O:33])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 12096122HCID 12096122, compound

Product 1

HCID 12096123HCID 12096123, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of the compound of Example 147 in dichloromethane (10 ml) is added trifluoroacetic acid (10 ml), and the mixture is stirred at 25° C. overnight. The solvent is evaporated under reduced pressure, and the residue is purified by CHP-20 (eluent: gradient, 35% to 100% methanol/0.05% aqueous trifluoroacetic acid solution) to give the title compound (200 mg).

Workup

  1. customThe solvent is evaporated under reduced pressure
  2. customthe residue is purified by CHP-20 (eluent: gradient, 35% to 100% methanol/0.05% aqueous trifluoroacetic acid solution)

Sources & evidence

ORD record
ord-573d13ca92614f0b83a106f325606f64
Source dataset
uspto-grants-2007_02
Patent number
US07176199B2

Reaction notes

Loading…