Methylamine → HCID 178485047, compound

HRID 34780Notes

Reaction equation

HRID 34780 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19](=[N:22][C:23]#[N:24])SC)[N:8]=1.[CH3:28][NH2:29]>C(O)C>[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]([NH:29][CH3:28])=[N:22][C:23]#[N:24])[N:8]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178503915HCID 178503915, compound

Product 1

HCID 178485047HCID 178485047, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(3-cyano-2-methylisothioureido)butylthio]pyrimidine (0.17 g.) in 33% w/v methylamine in ethanol was left at room temperature for 18 hours and then evaporated to dryness. The residue was triturated with ether and the insoluble solid collected and recrystallised from ethyl acetate to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(2-cyano-3-methylguanidino)butylthio]pyrimidine, m.p. 179°-180°.

Workup

  1. customevaporated to dryness
  2. customThe residue was triturated with ether
  3. customthe insoluble solid collected
  4. customrecrystallised from ethyl acetate

Sources & evidence

ORD record
ord-fc1d596c752c4b029af49257fbc274b8
Source dataset
uspto-grants-1988_08
Patent number
US04762932

Reaction notes

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