4'-Methoxybiphenyl-4-sulfonyl chloride → Ethyl 2-{[4'-methoxy(1,1'-biphenyl)-4-yl]sulfonyl}-2-azabicyclo[2.2.2]octane-3-carboxylate

HRID 347821Notes

Reaction equation

HRID 347821 reaction equation
[CH:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[NH:2]2.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=2)=[CH:18][CH:17]=1>>[CH3:14][O:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:27]=[CH:26][C:25]([S:28]([N:2]3[CH:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:4]4[CH2:5][CH2:6][CH:1]3[CH2:8][CH2:7]4)(=[O:30])=[O:29])=[CH:24][CH:23]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 27947504'-Methoxybiphenyl-4-sulfonyl chlorideHCID 19417395Ethyl 2-azabicyclo[2.2.2]octane-3-carboxylate

Product 1

HCID 21084205Ethyl 2-{[4'-methoxy(1,1'-biphenyl)-4-yl]sulfonyl}-2-azabicyclo[2.2.2]octane-3-carboxylate

Procedure

Ethyl 2-azabicyclo[2.2.2]octane-3-carboxylate is subjected to a reaction similar to the reaction (c) of Example 1 using [4-(4-methoxyphenyl)phenyl]sulfonyl chloride in place of 4-methoxybenzenesulfonyl chloride, to give ethyl 2-{[4′-methoxy(1,1′-biphenyl)-4-yl]sulfonyl}-2-azabicyclo[2.2.2]octane-3-carboxylate.

Sources & evidence

ORD record
ord-d3ac2d90b01f4312aba93af8f81d8330
Source dataset
uspto-grants-2007_02
Patent number
US07176217B2

Reaction notes

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