HRID347940

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID2733960

Thiophene-2-boronic acid

C4H5BO2S

HCID10927077

3-Iodo-1-(phenylsulfonyl)indole

C14H10INO2S

HCID21084554

未命名化合物

PRODUCTS

生成物

结构：O=S(=O)(c1ccccc1)n1c(-c2ccsc2)cc2ccccc21

HCID10569099

未命名化合物

收率 75%

AUXILIARIES

试剂、催化剂与溶剂

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

催化剂HCID178418397

未命名化合物

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

N-Benzenesulfonyl-3-iodoindole (11), 2-thiopheneboronic acid, Pd(PPh3)4 and K2CO3 in toluene are allowed to react in the same manner as described in the preparation of compound 3 to give 0.33 g (75%) of 13: 1H NMR (CDCl3): δ7.97 (d, 1H, J=8.16 Hz), 7.79–7.16 (m, 3H), 7.70 (s, 1H), 7.18–7.46 (m, 7H), 7.03–7.08 (m, 1H).

WORKUP

后处理

customto react in the same manner

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a7c470acbed64a51843fdc016e3eef65
来源数据集: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07176230B2
来源说明: uspto-grants-2007_02

反应 SMILES

[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12](I)=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:20]1[CH:24]=[CH:23][CH:22]=[C:21]1B(O)O.C([O-])([O-])=O.[K+].[K+].C(N1C2C(=CC=CC=2)C=C1C1C=COC=1)C1C=CC=CC=1>C1(C)C=CC=CC=1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2[C:22]2[CH:23]=[CH:24][S:20][CH:21]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1