反应详情

1.2 g (3.7 mmol) 1,5-diacetyl-3-[pyrazin-2-yl-hydroxy-methylidene]-2-indolinone (Ex. V.23) are dissolved in 50 ml dioxane and refluxed with 2 ml carbon tetrachloride and 2 g triphenylphosphine for 5 h. Then the mixture is left to cool and evaporated down. The residue is chromatographed through a silica gel column with methylene chloride/methanol 25:1, the corresponding fractions are combined and concentrated by rotary evaporation.

1. waitThen the mixture is left
2. temperatureto cool
3. customevaporated down
4. customThe residue is chromatographed through a silica gel column with methylene chloride/methanol 25:1
5. concentrationconcentrated by rotary evaporation