反应详情

To a mixture of 7-chloro-2-(2-chlorophenyl)-3-iodopyrazolo[1,5-a]pyrimidine (I-1A-1d; 6.80 g, 17.4 mmol) in ethanol (175 ml) was added NaH (60% dispersion in oil, 439 mg, 18 mmol), portionwise. After stirring overnight, the suspended solids were isolated by vacuum filtration to afford, after drying, in vacuo, product I-11A-1a (6.87 g, 99%) as a solid: +APcI MS (M+1) 400.0; 1H NMR (400 MHz, CD3OD) δ 8.51 (d, J=5.0 Hz, 1H), 7.58–7.40 (m, 4H), 6.67 (d, J=5.0 Hz, 1H), 4.58 (q, J=7.1 Hz, 2H), 1.58 (t, J=7.1 Hz, 3H).

1. customthe suspended solids were isolated by vacuum filtration
2. customto afford
3. customafter drying, in vacuo, product I-11A-1a (6.87 g, 99%) as a solid