Methylamine → HCID 178485207, compound

HRID 34805Notes

Reaction equation

HRID 34805 reaction equation
[F:1][C:2]([F:28])([F:27])[CH2:3][N:4]=[C:5]([NH2:26])[NH:6][C:7]1[S:8][C:9]([CH3:25])=[C:10]([CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[N:20][S:21]([CH3:24])(=[O:23])=[O:22])SC)[N:11]=1.[CH3:29][NH2:30]>>[F:28][C:2]([F:1])([F:27])[CH2:3][N:4]=[C:5]([NH2:26])[NH:6][C:7]1[S:8][C:9]([CH3:25])=[C:10]([CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17]([NH:30][CH3:29])=[N:20][S:21]([CH3:24])(=[O:22])=[O:23])[N:11]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 1785040692-[2-(2,2,2-Trifluoroethyl)guanidino]-4-[4-(3-methylsulphonyl-2-methylisothioureido)butyl]-5-methylthiazole

Product 1

HCID 178485207HCID 178485207, compound

Procedure

To the 2-[2-(2,2,2-trifluoroethyl)guanidino]-4-[4-(3-methylsulphonyl-2-methylisothioureido)butyl]-5-methylthiazole was added a 30% w/v ethanolic solution of methylamine (5 ml.) and the mixture allowed to stand overnight at ambient temperature. It was then evaporated to dryness and 2-[2-(2,2,2-trifluoroethyl)guanidino]-4-[4-(2-methylsulphonyl-3-methylguanidino)butyl]-5-methylthiazole (0.17 g.) was isolated as the maleate salt from acetone, m.p. 165°-166°.

Workup

  1. customIt was then evaporated to dryness

Sources & evidence

ORD record
ord-7f2a5856312a4144b04f136f17a9412e
Source dataset
uspto-grants-1988_08
Patent number
US04762932

Reaction notes

Loading…