反应详情

A solution of intermediate 96, 5-fluoro-2-(1H-1,2,4-triazol-1-yl)benzonitrile (2.94 g, 15.59 mmol) in ethanol (100 mL) and 1N HCl (50 mL) was degassed by bubbling N2. Then, 10% Pd/C was added, the flask evacuated and vented to H2 three times and left on a Parr shaker under a H2 atmosphere (40 psi). After 6 h, the reaction mixture was filtered, concentrated and the aqueous solution lyophilized to afford the title compound (4.07 g, 98%) as a white powder. LCMS (M+H) calcd for C9H10FN4: 193.09; found: 193.15.

1. customby bubbling N2
2. additionThen, 10% Pd/C was added
3. customthe flask evacuated
4. waitleft on a Parr shaker under a H2 atmosphere (40 psi)
5. filtrationthe reaction mixture was filtered
6. concentrationconcentrated