反应详情

A mixture of 2-(3-fluoro-phenoxy)-3-(4-hydroxyphenyl)-2-methyl-propionic acid ethyl ester (0.030 mmol) (see Ex. 20, Part C), toluene-4-sulfonic acid 2-(5-methyl-2-biphenyl-4-yl-oxazol-4-yl)ethyl ester (0.030 mmol) (see Ex. 1, Part I) and 325 mesh K2CO3 (0.084 g, 0.60 mmol) in ethanol (2 mL) was heated to reflux for 24 h under N2. Aqueous 5N NaOH (0.5 mL) and additional ethanol (1 mL) was added to the reaction mixture and it was heated at reflux for an additional 2 h. The reaction was cooled and the solvent removed in vacuo. The residue was acidified with aqueous 1 N HCl (5 mL), extracted with water and CH2Cl2 and the organic layer dried by passing it through a Varian Chem Elut 1003 cartridge. The solvent was removed in vacuo to give 3-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-(3-fluoro-phenoxy)-2-methyl-propionic acid 1H NMR (400 MHz, CDCl3) δ 8.06 (d, 2H, J=8.2 Hz), 7.71 (d, 2H, J=8.2 MHz), 7.63 (d, 2H, J=7.0 Hz), 7.47 (t, 2H, J=7.6 Hz), 7.41–7.38 (m, 1H), 7.21–7.15 (m, 3H), 6.82 (d, 2H, J=8.6 Hz), 6.76–6.60 (m, 3H), 4.22 (t, 2H, J=6.3 Hz), 3.27 (d, 1H, J=14.1 Hz), 3.13 (d, 1H, J=14.1 Hz), 3.08 (t, 2H, J=6.3 Hz), 2.45 (s, 3H), 1.44 (s, 3H). MS (ES+) m/z exact mass calcd for C34H30FNO5 552.2186, found 552.2183.

1. temperaturewas heated
2. temperatureto reflux for 24 h under N2
3. temperaturewas heated
4. temperatureat reflux for an additional 2 h
5. temperatureThe reaction was cooled
6. customthe solvent removed in vacuo
7. extractionextracted with water and CH2Cl2
8. customthe organic layer dried
9. customThe solvent was removed in vacuo