p-Tolyloxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester → 3-(4-Hydroxyphenyl)-2-methyl-2-p-tolyloxypropionic acid ethyl ester

HRID 348338Notes

Reaction equation

HRID 348338 reaction equation
[CH2:1]([O:3][C:4](=[O:30])[C:5]([O:22][C:23]1[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=1)([CH3:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:30])[C:5]([O:22][C:23]1[CH:24]=[CH:25][C:26]([CH3:29])=[CH:27][CH:28]=1)([CH3:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 69353334p-Tolyloxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester

Product 1

HCID 693150933-(4-Hydroxyphenyl)-2-methyl-2-p-tolyloxypropionic acid ethyl ester

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

2-(p-Tolyloxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester (2.1 mmol) was dissolved in ethyl acetate (30 mL) and treated with 5% palladium on carbon (300 mg), and stirred under an atmosphere of hydrogen for 20 h. The suspension was filtered through celite and concentrated in vacuo to an oil.

Workup

  1. filtrationThe suspension was filtered through celite and
  2. concentrationconcentrated in vacuo to an oil

Sources & evidence

ORD record
ord-74fa58ca36964cbd924e3b6a1d862a1a
Source dataset
uspto-grants-2007_02
Patent number
US07176224B2

Reaction notes

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