Ammonium Chloride → HCID 135790085, compound

HRID 348409Notes

Reaction equation

HRID 348409 reaction equation
[CH2:1]([O:3][C:4]1[C:9]([C:10]2[NH:11][C:12](=[O:30])[C:13]3[C:14](=[C:16]([CH2:28][CH3:29])[N:17]([C:19]4[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=4)[N:18]=3)[N:15]=2)=[CH:8][C:7]([S:31]([N:34]2[CH2:39][CH2:38][N:37]([CH2:40][CH3:41])[CH2:36][CH2:35]2)(=[O:33])=[O:32])=[CH:6][N:5]=1)[CH3:2].[Cl-].[NH4+]>CO.O.[Fe]>[NH2:25][C:22]1[CH:21]=[CH:20][C:19]([N:17]2[C:16]([CH2:28][CH3:29])=[C:14]3[N:15]=[C:10]([C:9]4[C:4]([O:3][CH2:1][CH3:2])=[N:5][CH:6]=[C:7]([S:31]([N:34]5[CH2:35][CH2:36][N:37]([CH2:40][CH3:41])[CH2:38][CH2:39]5)(=[O:32])=[O:33])[CH:8]=4)[NH:11][C:12](=[O:30])[C:13]3=[N:18]2)=[CH:24][CH:23]=1

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 135790099HCID 135790099, compound

Product 1

HCID 135790085HCID 135790085, compound

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

A solution of the title compound from example 63 (100 mg, 0.17 mmol) in methanol (2 ml) was added to a suspension of iron powder (29 mg, 0.52 mmol) in ammonium chloride (45 mg, 0.85 mmol) in water (2 ml), and the reaction heated at 60° C. for 1 hour. The cooled mixture was filtered, and the filtrate evaporated under reduced pressure to give the title compound as a pale brown solid, 93 mg.

Workup

  1. filtrationThe cooled mixture was filtered
  2. customthe filtrate evaporated under reduced pressure

Sources & evidence

ORD record
ord-41561f54097347a7b71b4ea2a8ddc698
Source dataset
uspto-grants-2007_02
Patent number
US07176311B2

Reaction notes

Loading…