1-Methoxy-2-propanol → 24590-51-0

HRID 348415Notes

Reaction equation

HRID 348415 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][O:7][CH2:8][CH:9]([OH:11])[CH3:10].C(N(CC)CC)C>ClCCl>[CH3:1][S:2]([O:11][CH:9]([CH3:10])[CH2:8][O:7][CH3:6])(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 79001-Methoxy-2-propanolHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

Product 1

HCID 9792024590-51-0

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methanesulphonyl chloride (2.86 ml, 36.9 mmol) was added dropwise to an ice-cooled solution of 1-methoxy-2-propanol (3 ml, 30.7 mmol) and triethylamine (10.27 ml, 73.7 mmol) in dichloromethane (150 ml), and the reaction stirred at room temperature for 18 hours. The mixture was washed with water, then 2M hydrochloric acid, dried (MgSO4) and evaporated under reduced pressure to give the title compound as a yellow oil, 5.24 g.

Workup

  1. washThe mixture was washed with water
  2. dry with material2M hydrochloric acid, dried (MgSO4)
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-c4c360e675494b0899a78274283733c0
Source dataset
uspto-grants-2007_02
Patent number
US07176311B2

Reaction notes

Loading…