Isopropanol → HCID 69523042, compound

HRID 348458Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[N:15][CH:16]=2)=[O:10])=[CH:4][CH:3]=1.[CH:22](O)([CH3:24])[CH3:23]>>[CH:22]([O:20][C:19](=[O:21])[CH2:18][O:17][C:14]1[N:13]=[CH:12][C:11]([C:9](=[O:10])[NH:8][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[CH:16][N:15]=1)([CH3:24])[CH3:23]

Participants

Reactant 2

HCID 3776Isopropanol

HCID 21087356[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid

Product 1

HCID 69523042HCID 69523042, compoundYield 92%

Procedure

The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using isopropanol (100 μL, 1.3 mmol) as the coupling partner. Concentration (no chromatography) yielded 52 mg (92%) of the titled compound.

Workup

concentrationConcentration (no chromatography)

Sources & evidence

ORD record: ord-62fe1436d42643018a568b400711502e
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07176310B1

Reaction notes

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