3-Aminopyridine → HCID 86760389, compound

HRID 348477Notes

Reaction equation

HRID 348477 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH2:18][C:19]([OH:21])=O)=[N:15][CH:16]=2)=[O:10])=[CH:4][CH:3]=1.[NH2:22][C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[CH:16]=[N:15][C:14]([O:17][CH2:18][C:19](=[O:21])[NH:22][C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[N:13][CH:12]=2)=[O:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 100093-AminopyridineHCID 21087356[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid

Product 1

HCID 86760389HCID 86760389, compoundYield 27%

Procedure

The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 3-aminopyridine (20 mg, 0.21 mmol) as the coupling partner. Concentration (no chromatography) yielded 17 mg (27%) of the titled compound. ESI-MS m/z 368 (MH+), 366 (M−H−).

Workup

  1. concentrationConcentration (no chromatography)

Sources & evidence

ORD record
ord-813657f74dc84aa2a169de87d811f7bb
Source dataset
uspto-grants-2007_02
Patent number
US07176310B1

Reaction notes

Loading…