Cyclohexylamine → HCID 86760391, compound

HRID 348479Notes

Reaction equation

HRID 348479 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH2:18][C:19]([OH:21])=O)=[N:15][CH:16]=2)=[O:10])=[CH:4][CH:3]=1.[CH:22]1([NH2:28])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[CH:16]=[N:15][C:14]([O:17][CH2:18][C:19](=[O:21])[NH:28][CH:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[N:13][CH:12]=2)=[O:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 21087356[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid

Product 1

HCID 86760391HCID 86760391, compoundYield 57%

Procedure

The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using cyclohexylamine (24 μL, 0.21 mmol) as the coupling partner. Concentration (no chromatography) yielded 36 mg (57%) of the titled compound. ESI-MS m/z 373 (MH+), 371 (M−H−).

Workup

  1. concentrationConcentration (no chromatography)

Sources & evidence

ORD record
ord-9845525c9305467d8403a0014c286445
Source dataset
uspto-grants-2007_02
Patent number
US07176310B1

Reaction notes

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