Sulfuric Acid → 3-(5,5-Dimethyl-1,3-dioxan-2-yl)-1-(3,4-dimethylphenyl)butan-1-one

Participants

Reaction Conditions

Reaction Steps

2-Bromo-1-(3,4-dimethylphenyl)ethan-1-one (220 g) and N,N-bis(2-methylpropyl)-1-propenylamine (249 g) were added to 990 ml of dimethylformamide under an atmosphere of nitrogen and the mixture was stirred at around 50° C. for 2 hours. After cooling the reaction mixture to 10° C., 990 ml of water, 170 g of neopentyl glycol and 173 g of concentrated sulfuric acid were added successively to the reaction mixture and the mixture was stirred at around 60° C. for 2 hours. After cooling the reaction mixture to the room temperature, crystals precipitated. These crystals were isolated by filtration to give 262 g (yield 83%) of the title compound as white crystals.

Provenance & Evidence