反应详情

温度

50 °C

2-Bromo-1-(3,4-dimethylphenyl)ethan-1-one (220 g) and N,N-bis(2-methylpropyl)-1-propenylamine (249 g) were added to 990 ml of dimethylformamide under an atmosphere of nitrogen and the mixture was stirred at around 50° C. for 2 hours. After cooling the reaction mixture to 10° C., 990 ml of water, 170 g of neopentyl glycol and 173 g of concentrated sulfuric acid were added successively to the reaction mixture and the mixture was stirred at around 60° C. for 2 hours. After cooling the reaction mixture to the room temperature, crystals precipitated. These crystals were isolated by filtration to give 262 g (yield 83%) of the title compound as white crystals.

1. temperatureAfter cooling the reaction mixture to 10° C.
2. stirringthe mixture was stirred at around 60° C. for 2 hours
3. temperatureAfter cooling the reaction mixture to the room temperature, crystals
4. customprecipitated
5. customThese crystals were isolated by filtration