反应详情

温度

50 °C

2-Bromo-1-(3,4-dimethylphenyl)ethan-1-one (6.2 g) and N,N-bis(2-methylpropyl)-1-propenylamine (6.8 g) were added to 25 ml of acetonitrile under an atmosphere of nitrogen and the mixture was stirred at around 50° C. for 4 hours. After cooling the reaction mixture to 10° C., 25 ml of water, 4.3 g of neopentyl glycol, 6.2 g of concentrated sulfuric acid and 0.62 g of para-toluenesulfonic acid were added to the reaction mixture and the mixture was stirred at around 60° C. for 1 hour. After cooling the reaction mixture to the room temperature, crystals precipitated. These crystals were isolated by filtration to give 6.6 g (yield 84%) of the title compound as white crystals.

1. temperatureAfter cooling the reaction mixture to 10° C.
2. stirringthe mixture was stirred at around 60° C. for 1 hour
3. temperatureAfter cooling the reaction mixture to the room temperature, crystals
4. customprecipitated
5. customThese crystals were isolated by filtration