Hydrochloric Acid → HCID 10435884, compound

HRID 348625Notes

Reaction equation

HRID 348625 reaction equation
C(OC(=O)[N:7]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:43])[C:23]2[CH:28]=[CH:27][C:26]([CH2:29][N:30]([CH2:37][C:38]3[NH:39][CH:40]=[CH:41][N:42]=3)[CH2:31][C:32]3[NH:33][CH:34]=[CH:35][N:36]=3)=[CH:25][CH:24]=2)=[CH:17][CH:16]=1)[CH2:8][C:9]1[NH:10][CH:11]=[CH:12][N:13]=1)(C)(C)C.Cl>CO>[NH:33]1[CH:34]=[CH:35][N:36]=[C:32]1[CH2:31][N:30]([CH2:29][C:26]1[CH:25]=[CH:24][C:23]([C:22]([NH:21][C:18]2[CH:19]=[CH:20][C:15]([CH2:14][NH:7][CH2:8][C:9]3[NH:10][CH:11]=[CH:12][N:13]=3)=[CH:16][CH:17]=2)=[O:43])=[CH:28][CH:27]=1)[CH2:37][C:38]1[NH:42][CH:41]=[CH:40][N:39]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66941341HCID 66941341, compound

Product 1

HCID 10435884HCID 10435884, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound (105 mg) obtained in Example 34-4 was dissolved in methanol (10 ml) and then added with 1 mol/l hydrochloric acid (2.0 ml), followed by stirring at room temperature for 5 minutes. The solution was concentrated and dried, and then purified through column chromatography (chloroform/methanol), thereby obtaining hydrochloride (64 mg) of the subject compound as a white solid.

Workup

  1. concentrationThe solution was concentrated
  2. customdried
  3. custompurified through column chromatography (chloroform/methanol)

Sources & evidence

ORD record
ord-fda7be87b5d34e56b5e186ee607aabc6
Source dataset
uspto-grants-2007_02
Patent number
US07176227B2

Reaction notes

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