HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 4-Dimethylamino-6-methoxy-2-(4-tolylsulfonyl)methylamino-1,3,5-triazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | 6-Methoxy-N2,N2-dimethyl-1,3,5-triazine-2,4-diamine | HCID 793255 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3-Methylbenzene-1-sulfinic acid | HCID 13787189 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Dimethylamino-6-methoxy-2-(4-tolylsulfonyl)methylamino-1,3,5-triazine | HCID 23043227 | — |
Reaction Steps
8.5 g (0.05 mole) of 2-amino-4-dimethylamino-6-methoxy-1,3,5-triazine and 9.1 g (0.05 mole) of toluene-5-sulfinic acid, sodium salt, are suspended in 100 ml of methanol and to the stirred suspension are added, in succession, 4.8 g (0.05 mole) of methanesulfonic acid and 4.7 g (0.055 mole) of aqueous 35% formaldehyde. The batch is then stirred for 30 minutes at room temperature and then for another 90 minutes under reflux. After cooling, the mixture is diluted with 1 liter of water and the crystalline precipitate is filtered with suction and dried. Melting point: 188°-190° C. Yield: 10 g (59% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764203 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-ace731a5e685484499b5db0356780d80 |
| Source note | uspto-grants-1988_08 |