Ether hydrochloride → N-(4-{[(1H-imidazol-2-ylmethyl)-(5-methylpyridine-2-ylmethyl)-amino]-methyl}-benzyl)-N',N'-dipropylbutane-1,4-diamine

HRID 348672Notes

Reaction equation

C(OC(=O)[N:7]([CH2:31][CH2:32][CH2:33][CH2:34][N:35]([CH2:39][CH2:40][CH3:41])[CH2:36][CH2:37][CH3:38])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:16]([CH2:25][C:26]2[NH:27][CH:28]=[CH:29][N:30]=2)[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=2)=[CH:11][CH:10]=1)(C)(C)C.Cl.C(OCC)C>CO>[NH:27]1[CH:28]=[CH:29][N:30]=[C:26]1[CH2:25][N:16]([CH2:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][NH:7][CH2:31][CH2:32][CH2:33][CH2:34][N:35]([CH2:36][CH2:37][CH3:38])[CH2:39][CH2:40][CH3:41])=[CH:10][CH:11]=1)[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=1

Participants

Conditions

Temperature: 40 °C

Procedure

The compound (35.5 mg) obtained in Example 75-2 was dissolved in methanol (1.0 ml) and then added with a 1 mol/l hydrogen chloride/diethyl ether solution (2 ml), followed by stirring at 40° C. for 1 hour. The solvent was distilled off, thereby obtaining hydrochloride (36.9 mg) of the subject compound as a yellow solid.

Workup

distillationThe solvent was distilled off

Sources & evidence

ORD record: ord-4e48b422568f43248cd62b52e24907da
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07176227B2

Reaction notes

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