HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 348672Generated: October 29, 2026
Ether hydrochloride → N-(4-{[(1H-imidazol-2-ylmethyl)-(5-methylpyridine-2-ylmethyl)-amino]-methyl}-benzyl)-N',N'-dipropylbutane-1,4-diamine
https://huagongshe.com/reaction/348672
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ether hydrochloride | HCID 10953452 | — |
| Reactant | (4-dipropylaminobutyl)-(4-{[(1H-imidazol-2-ylmethyl)-(5-methylpyridin-2-ylmethyl)amino]methyl}benzyl)carbamic Acid t-butyl Ester | HCID 66941714 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(4-{[(1H-imidazol-2-ylmethyl)-(5-methylpyridine-2-ylmethyl)-amino]-methyl}-benzyl)-N',N'-dipropylbutane-1,4-diamine | HCID 10096551 | — |
Reaction Steps
The compound (35.5 mg) obtained in Example 75-2 was dissolved in methanol (1.0 ml) and then added with a 1 mol/l hydrogen chloride/diethyl ether solution (2 ml), followed by stirring at 40° C. for 1 hour. The solvent was distilled off, thereby obtaining hydrochloride (36.9 mg) of the subject compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07176227B2 |
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| Source dataset | uspto-grants-2007_02 |
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| ORD ID | ord-4e48b422568f43248cd62b52e24907da |
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| Source note | uspto-grants-2007_02 |
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