HCID 66941909, compound → HCID 69523813, compound

HRID 348709Notes

Reaction equation

HRID 348709 reaction equation
C(OC(=O)[NH:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][N:25]([CH2:33][C:34]2[NH:35][CH:36]=[CH:37][N:38]=2)[CH2:26][C:27]2[N:28]([CH3:32])[CH:29]=[CH:30][N:31]=2)=[CH:20][CH:19]=1)[CH3:16])C1C=CC=CC=1>CO.C(O)C.[C].[Pd]>[NH:38]1[CH:37]=[CH:36][N:35]=[C:34]1[CH2:33][N:25]([CH2:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:15]([CH3:16])[CH2:14][CH2:13][CH2:12][CH2:11][NH2:10])=[CH:19][CH:20]=1)[CH2:26][C:27]1[N:28]([CH3:32])[CH:29]=[CH:30][N:31]=1

Participants

5

Reactant 1

HCID 66941909HCID 66941909, compound

Product 1

HCID 69523813HCID 69523813, compoundYield 101.9%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

The compound (502.6 mg) obtained in Example 103-6 was dissolved in methanol (2.5 ml) and cooled with ice. Then, the solution was added with a suspension of 10% palladium-carbon (251.3 mg) in ethanol (2 ml), followed by stirring at room temperature for 2 hours under a hydrogen atmosphere. After the reaction, the solution was filtrated through Celite and the solvent was then distilled off, thereby obtaining the subject compound (382.4 mg) as a white solid.

Workup

  1. temperaturecooled with ice
  2. customAfter the reaction
  3. filtrationthe solution was filtrated through Celite
  4. distillationthe solvent was then distilled off

Sources & evidence

ORD record
ord-ac91dafe1fe04387a8a0ffebd0ffbcce
Source dataset
uspto-grants-2007_02
Patent number
US07176227B2

Reaction notes

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