反应详情

In carbon tetrachloride (26 ml), 2,6-dimethylquinoline (manufactured by Tokyo Kasei Kogyo Co., Ltd.) (1.0398 g), N-bromosuccinimide (1.2353 g), and azobisisobutyronitrile (98.5 mg) were dissolved and then the whole was subjected to thermal reflux for 2 hours under an argon atmosphere. After the reaction, a precipitate was removed through filtration and then washed with water, followed by drying with magnesium sulfate. The solvent was distilled off and the residue was then purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (427.3 mg) as a white solid.

1. temperaturethermal reflux for 2 hours under an argon atmosphere
2. customAfter the reaction
3. customa precipitate was removed through filtration
4. washwashed with water
5. dry with materialby drying with magnesium sulfate
6. distillationThe solvent was distilled off
7. customthe residue was then purified through silica gel column chromatography (hexane/ethyl acetate)