反应详情

The compound (675.0 mg) obtained in Example 123-1 was suspended in anhydrous THF (30 ml) and cooled with ice. Then, the suspension was added with a 2 mol/l lithium diisopropylamide/heptane solution (0.825 ml), followed by stirring at room temperature for 1 hour. Then, the solution was gradually added with a solution prepared by suspending the compound (327.9 mg) obtained in Example 119-7 in anhydrous THF (20 ml), followed by stirring at room temperature for 3 hours. After completion of the reaction, the solvent was distilled off and the residue was then purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (268.0 mg) as a yellow solid.

1. temperaturecooled with ice
2. additionThen, the solution was gradually added with a solution
3. customprepared
4. stirringby stirring at room temperature for 3 hours
5. customAfter completion of the reaction
6. distillationthe solvent was distilled off
7. customthe residue was then purified through silica gel column chromatography (chloroform/ethyl acetate)