反应详情

The compound (95.7 mg) obtained in Example 127-12 was dissolved in methanol (4.79 ml) and added with hydrazine monohydrate (0.0957 ml), followed by thermal reflux for 1 hour. The reaction solution was concentrated under reduced pressure. Then, the residue was added with water and subjected to separation/extraction with chloroform, dried with anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (45.0 mg) as a yellow oily substance.

1. temperatureby thermal reflux for 1 hour
2. concentrationThe reaction solution was concentrated under reduced pressure
3. additionThen, the residue was added with water
4. extractionsubjected to separation/extraction with chloroform
5. dry with materialdried with anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue was purified through silica gel column chromatography (chloroform/ethyl acetate)