Lithium Hydroxide → HCID 21085837, compound

HRID 348845Notes

Reaction equation

HRID 348845 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)[CH:11]=1)[C:5]([O:7]C)=[O:6].[OH-].[Li+]>O1CCCC1.CO.O>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)[CH:11]=1)[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 21086188HCID 21086188, compound

Product 1

HCID 21085837HCID 21085837, compound

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

Methyl 3-methyl-5-(3-thienyl)benzoate (257 mg, 1.1 mmol) is treated with lithium hydroxide (186 mg, 4.4 mmol) in tetrahydrofuran/methanol/water (8 ml, 2:1:1) and the mixture is stirred for 2 hours at 20–25 degrees C. The mixture is acidified and concentrated to give the title compound, MS [M+H]+=217.0.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-fd4db1b2e67c4737a5d7d2242a3ec00b
Source dataset
uspto-grants-2007_02
Patent number
US07176242B2

Reaction notes

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