HRID348879

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCCN(CCC)C(=O)c1cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(C(C)C)c2)cc(-c2nccs2)c1

HCID58802278

未命名化合物

PRODUCTS

生成物

结构：CCCN(CCC)C(=O)c1cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(C(C)C)c2)cc(-c2nccs2)c1.Cl

HCID68608557

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

2 次

PROCEDURE

实验过程

N1-{(1S,2R)-1-(3,5-Difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide (180 mg, 0.27 mmol) is dissolved in diethyl ether (5 mL) and 1N hydrochloric acid in diethyl ether (2 mL) is added. The mixture is concentrated under reduced pressure to yield the title compound. ESI MS m/z 663.3 [M+H]+.

WORKUP

后处理

concentrationThe mixture is concentrated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f57943ce6d74414fade9b0b41a821038
来源数据集: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07176242B2
来源说明: uspto-grants-2007_02

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([CH:44]=[C:45]([F:47])[CH:46]=1)[CH2:5][C@H:6]([NH:21][C:22](=[O:43])[C:23]1[CH:37]=[C:36]([C:38]2[S:39][CH:40]=[CH:41][N:42]=2)[CH:35]=[C:25]([C:26]([N:28]([CH2:32][CH2:33][CH3:34])[CH2:29][CH2:30][CH3:31])=[O:27])[CH:24]=1)[C@H:7]([OH:20])[CH2:8][NH:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH:17]([CH3:19])[CH3:18])[CH:12]=1.[ClH:48]>C(OCC)C>[ClH:48].[F:1][C:2]1[CH:3]=[C:4]([CH:44]=[C:45]([F:47])[CH:46]=1)[CH2:5][C@H:6]([NH:21][C:22](=[O:43])[C:23]1[CH:37]=[C:36]([C:38]2[S:39][CH:40]=[CH:41][N:42]=2)[CH:35]=[C:25]([C:26]([N:28]([CH2:29][CH2:30][CH3:31])[CH2:32][CH2:33][CH3:34])=[O:27])[CH:24]=1)[C@H:7]([OH:20])[CH2:8][NH:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH:17]([CH3:19])[CH3:18])[CH:12]=1