Hydrochloric Acid → HCID 23045253, compound

HRID 34890Notes

Reaction equation

HRID 34890 reaction equation
[OH:1][CH:2]([CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8](=[O:12])[CH:9]([CH3:11])[CH3:10].[ClH:21]>CCOCC>[Cl-:21].[OH:1][CH:2]([CH2:13][O:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH2:3][NH2+:4][CH2:5][CH2:6][NH:7][C:8](=[O:12])[CH:9]([CH3:11])[CH3:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10356325(-)-N-(2-[2-hydroxy-3-phenoxypropyl]aminoethyl)isobutyramide

Product 1

HCID 23045253HCID 23045253, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of (-)-N-(2-[2-hydroxy-3-phenoxypropyl]aminoethyl)isobutyramide (0.7 g) in anhydrous ether (10 ml) was treated with an excess of a saturated solution of hydrogen chloride in anhydrous ether. The solid which formed was collected and recrystallised twice from a mixture of methanol and anhydrous ether to give (-)-N-[2-hydroxy-3-phenoxypropyl]-N-(2-isobutyramidoethyl)ammonium chloride, m.p. 137°-139° C; 25 [α]D -19.7° [c, 1.135; methanol]; microanalysis C15H24N2O3.HCl requires: C, 56.87; H, 7.90; N, 8.84; Cl, 11.20%; found: C, 56.80; H, 8.0; N, 8.6; Cl, 11.1%.

Workup

  1. customThe solid which formed
  2. customwas collected
  3. customrecrystallised twice from a mixture of methanol and anhydrous ether

Sources & evidence

ORD record
ord-c7132b10b3bb48e0af000c25012cbe3d
Source dataset
uspto-grants-1988_08
Patent number
US04764361

Reaction notes

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