反应详情

温度

5 °C

Into a mixture comprising 224 g of reduced iron, 13.4 g of ammonium chloride, 1 liter of isopropyl alcohol and 0.2 liter of water was added 237 g of ethyl p-nitrobenzoylacetate in small portions at a temperature between 50° C. and 70° C. with caution against heat generation. The mixture was allowed to react at 70° C. for 1 hour, followed by filtration. To the filtrate was added 1 liter of water, and crystals precipitated upon cooling to 5° C. were separated by filtration to obtain 172 g of ethyl p-aminobenzoylacetate as yellow crystals having a melting point of 82° to 84° C.

1. temperatureagainst heat generation
2. customto react at 70° C. for 1 hour
3. filtrationfollowed by filtration
4. additionTo the filtrate was added 1 liter of water, and crystals
5. customprecipitated
6. customwere separated by filtration