反应详情

A mixture of 6-(2-bromopropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone (2 g) prepared in Step 1, potassium acetate (2.64 g) and glacial acetic acid (20 ml) is refluxed for three hours. The reaction mixture is diluted with water and extracted with methylene chloride (3×50 ml) and the combined organic layers are washed with saturated aqueous sodium bicarbonate, dried, filtered and concentrated to obtain 6-(2-acetoxypropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone which is used in the next step.

1. temperatureis refluxed for three hours
2. extractionextracted with methylene chloride (3×50 ml)
3. washthe combined organic layers are washed with saturated aqueous sodium bicarbonate
4. customdried
5. filtrationfiltered
6. concentrationconcentrated