反应详情

A mixture of 2-(4-oxo-3-thiazolidinyl)propionic acid (2.00 g), 2.6-dimethylaniline (1.38 g), and dicyclohexylcarbodiimide (2.35 g) in chloroform (15 ml) was refluxed for 48 hours. The resultant precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with diethyl ether and recrystallized from ethanol to give N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide (1.45 g) as colorless prisms.

1. temperaturewas refluxed for 48 hours
2. customThe resultant precipitate was removed by filtration
3. customthe filtrate was evaporated in vacuo
4. customThe residue was triturated with diethyl ether
5. customrecrystallized from ethanol