反应详情

温度

90 °C

24 g (0.0911 mol) of N-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]acetamide (1) are introduced into a solution containing 75 ml of 37% hydrochloric acid and 165 ml of water in a 500 ml three-necked flask. The reaction medium is heated at 90° C. for 2 hours 30 minutes. After cooling, the medium is neutralized carefully with 75 ml of aqueous 35% sodium hydroxide (pH=approximately 8). The resulting solid is then filtered off, after which-it is washed with water until the washing waters are neutral. The product is then dried under vacuum over P2O5. 16.8 g (83%) of 1-(3-methyl-4-nitrophenyl)pyrrolidin-3-ylamine (2) are thus obtained in the form of a yellow solid.

1. temperatureAfter cooling
2. filtrationThe resulting solid is then filtered off
3. washafter which-it is washed with water until the washing waters
4. dry with materialThe product is then dried under vacuum over P2O5