p-METHYLACETOPHENONE → 1-p-Tolylethanol, (-)-

Washed phaseolus aureus L (green grams) 50 g. were taken into a conical flask and allowed to soak in deionised water (400 ml) for a period of 24 hr. 4-methylacetophenone (0.500 g; 0.0037 moles) I(c) was added to the soaked phaseolus aureus L (green grams) in the above water, covered and allowed to shake for 24 hr at 15–20° C. Then the green grams were filtered off and washed with deionised water (3×100 ml). The combined filtrate was extracted with chloroform (3×500 ml). The chloroform layer was dried and the crude product obtained (340 mg). Pure 1-(4-methylphenyl-(1S)-ethan-1-ol II(c) was obtained after column chromatography with silica gel using chloroform as eluent;

1. washWashed phaseolus aureus L (green grams) 50 g
2. customwere taken into a conical flask
3. waitto shake for 24 hr at 15–20° C
4. filtrationThen the green grams were filtered off
5. washwashed with deionised water (3×100 ml)
6. extractionThe combined filtrate was extracted with chloroform (3×500 ml)
7. dry with materialThe chloroform layer was dried
8. customthe crude product obtained (340 mg)

ORD record

ord-24f4b716a0ae4932b168073bb939b5ee

Source dataset

uspto-grants-2007_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07179624B2