反应详情

A mixture of 3-(5,6,7,8-tetrahydroquinol-8-yl)propylamine (4.5 g), 2-chloro-3-nitro-5-(pyrid-3-ylmethyl)pyridine hydrochloride (5 g) and triethylamine (10 ml) was refluxed in ethanol (200 ml) for 7.5 hours. The solvent was removed in vacuo, the residue was dissolved in chloroform and chromatographed on silica in chloroform and later chloroform/methanol 4:1. The fractions containing the product were concentrated to give the title compound as an oil (6.1 g).

1. customThe solvent was removed in vacuo
2. dissolutionthe residue was dissolved in chloroform
3. customchromatographed on silica in chloroform and later chloroform/methanol 4:1
4. additionThe fractions containing the product
5. concentrationwere concentrated