反应详情

3-(4-[1,2,3]Triazol-1-yl-but-1-ynyl)-6-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-oxazol-4-ylmethoxy}-pyridazine (0.047 g, 0.1 mmol) is dissolved in ethyl acetate (3 ml) and hydrogenated for 3 h at r.t. in the presence of palladium on charcoal (10%, 20 mg). After filtration and concentration in vacuo the residue is purified by flash column chromatography (ethyl acetate/methanol 19:1) yielding 3-(4-[1,2,3]triazol-1-yl-butyl)-6-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-oxazol-4-ylmethoxy}-pyridazine as an off-white solid.

1. filtrationAfter filtration and concentration in vacuo the residue
2. customis purified by flash column chromatography (ethyl acetate/methanol 19:1)