反应详情

3-(4-[1,2,3]Triazol-1-yl-but-1-ynyl)-6-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-oxazol-4-ylmethoxy}-pyridazine (0.047 g, 0.1 mmol) is dissolved in ethyl acetate (3 ml) and hydrogenated for 1 h at r.t. in the presence of palladium on charcoal (10%, 5 mg). After filtration and concentration in vacuo the residue yielded 3-(4-[1,2,3]triazol-1-yl-but-1-enyl)-6-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-oxazol-4-ylmethoxy}-pyridazine as an off-white solid. The raw product contained 60% product and 40% educt. The ratio was detected by HPLC-MS (High Performance Liquid Chromatography-Mass Spectrometry; Eluent: H2O/CH3CN, Gradient: in 20 minutes from 0% (volume to volume (v/v)) to 95% (v/v) CH3CN, UV-detection at 226 nm).

1. filtrationAfter filtration and concentration in vacuo the residue