Water → 2-Bromo-5-(4-[1,2,3]triazol-1-yl-butyl)-pyrazine

HRID 349243Notes

Reaction equation

HRID 349243 reaction equation
[Br:1][C:2]1[CH:7]=[N:6][C:5]([C:8]#[C:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[N:13]2)=[CH:4][N:3]=1.O>CO.[Pt](=O)=O>[Br:1][C:2]1[CH:7]=[N:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[N:13]2)=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 962WaterHCID 442259082-Bromo-5-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrazine

Product 1

HCID 860740692-Bromo-5-(4-[1,2,3]triazol-1-yl-butyl)-pyrazine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 345198Adams' catalystSolvent

Procedure

2-Bromo-5-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrazine (2.50 g, 9.0 mmol) is dissolved in methanol (700 ml) and hydrogenated for 2 h at r.t. in the presence of platinum(IV) oxide ×H2O (0.840 g, 3.40 mmol). The reaction mixture is filtered and concentrated in vacuo to yield 2-bromo-5-(4-[1,2,3]triazol-1-yl-butyl)-pyrazine as a colorless solid. Yield 1.63 g (64%)

Workup

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-7a918fb4da244626babcf670c2188ab9
Source dataset
uspto-grants-2007_02
Patent number
US07179812B2

Reaction notes

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