反应详情

温度

65 °C

To a solution of [1-(3,5-Bis-trifluoromethyl-benzyl)-5-phenyl-1H-[1,2,3]triazol-4-yl]-(3-phenyl-5-trimethylsilanyl-3H-[1,2,3]triazol-4-yl)-methanone (0.050 g, 0.08 mmol) in THF (2 mL) add t-butyl ammonium flouride (1 M soln. in THF, 1.2 mL, 1.2 mmol) and acetic acid (120 μL, 2.0 mmol) and heat at 65° C. After 72 h., remove from heat, and quench with sat. aq. NH4C1 and H2O. Extract with EtOAc, dry over MgSO4, filter, and purify by flash chromatography (EtOAc/Hexane 0%–50%) to give the title compound. 1H NMR (300 MHz, CDCl3) δ 8.88 (s, 1H), 7.75 (s, 1H), 7.57–7.29 (m, 10H), 7.09 (m, 2H), 5.50 (s, 2H).

1. customremove
2. temperaturefrom heat
3. customquench with sat. aq. NH4C1 and H2O
4. extractionExtract with EtOAc
5. dry with materialdry over MgSO4
6. filtrationfilter
7. custompurify by flash chromatography (EtOAc/Hexane 0%–50%)