Hydrochloric Acid → N-(2-aminoethyl)-pyridine-2-carboxamide dihydrochloride

HRID 34933Notes

Reaction equation

HRID 34933 reaction equation
[NH:1]([CH2:5][CH2:6][NH:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)=[O:9])C(C)=O.[ClH:16]>>[ClH:16].[ClH:16].[NH2:1][CH2:5][CH2:6][NH:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)=[O:9]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11840576N-[2-(acetylamino)ethyl]-2-pyridinecarboxamide

Product 1

HCID 13031074N-(2-aminoethyl)-pyridine-2-carboxamide dihydrochloride

Procedure

12.0 g of N-(2-acetaminoethyl)-2-pyridine- carboxamide were suspended in 100 ml of alcohol and 116 ml of 2N hydrochloric acid and the suspension was heated to reflux overnight. The reaction mixture was thereafter concentrated under reduced pressure, the solid residue (13.4 g) was boiled up with methanol, cooled, suction filtered and dried. There was obtained N-(2-aminoethyl)-pyridine-2-carboxamide dihydrochloride as white crystals, m.p. 262° (dec.).

Workup

  1. temperatureto reflux overnight
  2. concentrationThe reaction mixture was thereafter concentrated under reduced pressure
  3. temperaturecooled
  4. filtrationsuction filtered
  5. customdried

Sources & evidence

ORD record
ord-db2823222c1e4d8188026bb193d9765e
Source dataset
uspto-grants-1988_08
Patent number
US04764522

Reaction notes

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