1,2-Diaminocyclohexane, trans- → HCID 69522581, compound

HRID 349387Notes

Reaction equation

HRID 349387 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH2:8].[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[C:11]=1[N:20]=[C:21]=[O:22]>C1COCC1>[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:21]([NH:20][C:11]1[C:12]([C:16]([F:17])([F:19])[F:18])=[CH:13][CH:14]=[CH:15][C:10]=1[Cl:9])=[O:22]

Participants

4

Reactant 2

HCID 438061,2-Diaminocyclohexane, trans-HCID 51423932-Chloro-6-(trifluoromethyl)phenyl isocyanate

Product 1

HCID 69522581HCID 69522581, compoundYield 42.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 0.46 g of trans-1,2-diaminocyclohexane in 10 ml of THF was added to a solution of 1.6 g of 2-chloro-6-trifluoromethylphenyl isocyanate in 30 ml of THF, and the mixture was stirred at room temperature for about 3 hours. The mixture was allowed to stand overnight and the solvent was then distilled off, giving 0.57 g of the desired compound as a semi-solid yellow product.

Workup

  1. waitto stand overnight
  2. distillationthe solvent was then distilled off

Sources & evidence

ORD record
ord-9cf38ad175b3402d9a8669e21ce506b0
Source dataset
uspto-grants-2007_02
Patent number
US07179829B2

Reaction notes

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