反应详情

A solution of 1.95 g of t-butyl [2-(3-benzyloxy-5-chloropyridine-2-carboxamido)ethyl]carbamate, m.p. 130°-133°, in 30 ml of trifluoroacetic acid was stirred at 50° for 7 hours. The mixture was thereafter evaporated to dryness on a rotary evaporator, the residue was dissolved in methanol and the solution was treated with hydrogen chloride in methanol (6N). After recrystallization from methanol there was obtained N-(2-aminoethyl)-3-hydroxy-5-chloropyridine-2-carboxamide hydrochloride, m.p. 220°-223°.

1. customThe mixture was thereafter evaporated to dryness on a rotary evaporator
2. dissolutionthe residue was dissolved in methanol
3. additionthe solution was treated with hydrogen chloride in methanol (6N)
4. customAfter recrystallization from methanol