4-Toluenesulfonyl chloride → 2-(2,6-Dimethylphenylamino)-1H-thieno[3,4-d]imidazole hydrochloride

HRID 349425Notes

Reaction equation

HRID 349425 reaction equation
[NH2:1][C:2]1[C:6]([NH:7][C:8]([NH:10][C:11]2[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:18])=S)=[CH:5][S:4][CH:3]=1.[OH-].[Na+].C1(C)C=CC(S([Cl:30])(=O)=O)=CC=1>>[ClH:30].[CH3:18][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]([CH3:17])[C:11]=1[NH:10][C:8]1[NH:7][C:6]2=[CH:5][S:4][CH:3]=[C:2]2[N:1]=1

Participants

4

Reactant 3

HCID 73974-Toluenesulfonyl chlorideHCID 14798Sodium HydroxideHCID 86037743N-(3-Amino-4-thienyl)-N'-(2,6-dimethylphenyl)thiourea

Product 1

HCID 695133922-(2,6-Dimethylphenylamino)-1H-thieno[3,4-d]imidazole hydrochloride

Procedure

was obtained in a similar manner to the method specified in Example 6b from 380 mg of N-(3-amino-4-thienyl)-N′-(2,6-dimethylphenyl)thiourea, 135.4 mg of NaOH and 287.3 mg of p-toluenesulfonyl chloride. Crystalline substance. M.p. >310° C.

Workup

  1. customwas obtained in a similar manner to the method

Sources & evidence

ORD record
ord-2e13f8583535401e9fb1b3785f81dfff
Source dataset
uspto-grants-2007_02
Patent number
US07179830B2

Reaction notes

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