Chloroform → HCID 22139803, compound

HRID 349428Notes

Reaction equation

HRID 349428 reaction equation
[C:1]([NH:4][C:5]1[CH:9]=C[S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2].S(Cl)([Cl:17])(=O)=O.[CH:19]([Cl:22])(Cl)Cl>>[C:1]([NH:4][C:5]1[C:9]([Cl:17])=[C:19]([Cl:22])[S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 6212Chloroform2×HCID 24648Sulfuryl chlorideHCID 729216methyl 3-acetamidothiophene-2-carboxylate

Product 1

HCID 22139803HCID 22139803, compound

Conditions

Temperature
40 °C

Procedure

was obtained by reacting 19.9 g of methyl 3-acetylaminothiophene-2-carboxylate in 100 ml of chloroform with 17.9 ml of sulfuryl chloride (SO2Cl2) in 120 ml of chloroform by stirring at 40° C. for 2 hours and subsequently boiling under reflux conditions for 15 minutes. After the solvent had been distilled off, the residue was crystallized in ethyl acetate.

Workup

  1. customwas obtained
  2. waitsubsequently boiling under reflux conditions for 15 minutes
  3. distillationAfter the solvent had been distilled off
  4. customthe residue was crystallized in ethyl acetate

Sources & evidence

ORD record
ord-1be62623a17a47cabd5b61e31375bf48
Source dataset
uspto-grants-2007_02
Patent number
US07179830B2

Reaction notes

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