Triethylamine → HCID 22139808, compound

HRID 349429Notes

Reaction equation

HRID 349429 reaction equation
[C:1]([NH:4][C:5]1[C:9]([Cl:10])=[C:8](Cl)[S:7][C:6]=1[C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2].C(N(CC)CC)C>CO.[Pd]>[C:1]([NH:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 22139803HCID 22139803, compound

Product 1

HCID 22139808HCID 22139808, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

was obtained by catalytically hydrogenating a mixture of 25 g of methyl 3-acetylamino-4,5-dichlorothiophene-2-carboxylate in 300 ml of methanol, 9.5 g of triethylamine and with 10 g of palladium on carbon and room temperature and 760 mmHg column (standard pressure conditions). After the calculated amount of hydrogen had been absorbed, the catalyst was filtered off, the solvent was distilled off on a Rotavapor and the product was crystallized under water.

Workup

  1. customwas obtained by catalytically hydrogenating
  2. customAfter the calculated amount of hydrogen had been absorbed
  3. filtrationthe catalyst was filtered off
  4. distillationthe solvent was distilled off on a Rotavapor
  5. customthe product was crystallized under water

Sources & evidence

ORD record
ord-3d1a83c62a774dabbb0f41561cafa9b7
Source dataset
uspto-grants-2007_02
Patent number
US07179830B2

Reaction notes

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