HCID 22139808, compound → methyl 3-amino-4-chlorothiophene-2-carboxylate

HRID 349430Notes

Reaction equation

HRID 349430 reaction equation
C([NH:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:11]([O:13][CH3:14])=[O:12])(=O)C>CO.Cl>[NH2:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:11]([O:13][CH3:14])=[O:12]

Participants

4

Reactant 1

HCID 22139808HCID 22139808, compound

Product 1

HCID 22139844methyl 3-amino-4-chlorothiophene-2-carboxylate

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

was obtained by stirring a solution of 7 g of methyl 3-acetylamino-4-chlorothiophene-2-carboxylate in a mixture of 50 ml of methanol and 50 ml of concentrated hydrochloric acid at 60° C. for 4 hours and at room temperature for 2 days. The mixture was filtered, the solvent was distilled to about ⅓ of the starting volume, approx. 100 ml of water were added and the crystals were filtered off after stirring at room temperature. Crystalline product. M.p. 62–64° C.

Workup

  1. customwas obtained
  2. filtrationThe mixture was filtered
  3. distillationthe solvent was distilled to about ⅓ of the starting volume, approx. 100 ml of water
  4. additionwere added
  5. filtrationthe crystals were filtered off

Sources & evidence

ORD record
ord-7f266a2370f04a3e9cd7fc83367554db
Source dataset
uspto-grants-2007_02
Patent number
US07179830B2

Reaction notes

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