Sodium Bicarbonate → 2-(2-chloro-4-methyl-3-thienylamino)-1H-thieno[3,4-d]imidazole

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Reaction Steps

is obtained by adding saturated sodium hydrogencarbonate solution to a suspension of 306 mg of 2-(2-chloro-4-methyl-3-thienylamino)-1H-thieno[3,4-d]imidazole hydrochloride (example 5) in 40 ml of water, in the course of which a pH of 10 is established. After the suspension had been stirred at room temperature for 1 hour, the solid was filtered off and washed repeatedly with water, and the product was dried in an air stream. Colorless crystalline product, decomposition point from 180° C. Pharmacological Data: Determination of the NHE Inhibition Test Description:

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