Sodium Bicarbonate → 2-(2-chloro-4-methyl-3-thienylamino)-1H-thieno[3,4-d]imidazole

HRID 349434Notes

Reaction equation

HRID 349434 reaction equation
C(=O)([O-])O.[Na+].Cl.[Cl:7][C:8]1[S:9][CH:10]=[C:11]([CH3:22])[C:12]=1[NH:13][C:14]1[NH:18][C:17]2=[CH:19][S:20][CH:21]=[C:16]2[N:15]=1>O>[Cl:7][C:8]1[S:9][CH:10]=[C:11]([CH3:22])[C:12]=1[NH:13][C:14]1[NH:15][C:16]2=[CH:21][S:20][CH:19]=[C:17]2[N:18]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 114267352-(2-Chloro-4-methyl-3-thienylamino)-1H-thieno[3,4-d]imidazole hydrochloride

Product 1

HCID 114256822-(2-chloro-4-methyl-3-thienylamino)-1H-thieno[3,4-d]imidazole

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

is obtained by adding saturated sodium hydrogencarbonate solution to a suspension of 306 mg of 2-(2-chloro-4-methyl-3-thienylamino)-1H-thieno[3,4-d]imidazole hydrochloride (example 5) in 40 ml of water, in the course of which a pH of 10 is established. After the suspension had been stirred at room temperature for 1 hour, the solid was filtered off and washed repeatedly with water, and the product was dried in an air stream. Colorless crystalline product, decomposition point from 180° C. Pharmacological Data: Determination of the NHE Inhibition Test Description:

Workup

  1. customis obtained
  2. filtrationthe solid was filtered off
  3. washwashed repeatedly with water
  4. customthe product was dried in an air stream
  5. customfrom 180° C

Sources & evidence

ORD record
ord-982595a4aa9a4b9981688a1bdc94d81e
Source dataset
uspto-grants-2007_02
Patent number
US07179830B2

Reaction notes

Loading…