反应详情

A solution of 1.6 g of t-butyl [2-(5-chloropyrazine-2-carboxamido)ethyl]carbamate in 6 ml of trifluoroacetic acid was stirred at 20° for 20 minutes. The mixture was thereafter evaporated to dryness on a rotary evaporator, the residue was dissolved in methanol and the solution was treated with hydrogen chloride in methanol (6N). After recrystallization from methanol/diethyl ether there was obtained N-(2-aminoethyl)-5-chloropyrazine-2-carboxamide hydrochloride, m.p. 225°.

1. customThe mixture was thereafter evaporated to dryness on a rotary evaporator
2. dissolutionthe residue was dissolved in methanol
3. additionthe solution was treated with hydrogen chloride in methanol (6N)
4. customAfter recrystallization from methanol/diethyl ether there